Structure-activity relationships of the 7-substituents of 5, 4'-diamino-6, 8, 3'-trifluoroflavone, a potent antitumor agent

T Akama, H Ishida, U Kimura, K Gomi…

Index: Akama, Tsutomu; Ishida, Hiroyuki; Kimura, Uichiro; Gomi, Katsushige; Saito, Hiromitsu Journal of Medicinal Chemistry, 1998 , vol. 41, # 12 p. 2056 - 2067

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Citation Number: 57

Abstract

Recently, we reported that 5, 4'-diamino-6, 8, 3'-trifluoroflavone (1b) exhibits potent antitumor activity against certain types of human cancer cell lines both in vitro and in vivo. Since the antiproliferative activity of 5, 4'-diaminoflavone (1a), the lead compound of 1b, was modulated by the addition of apigenin, we hypothesized that the 7-position is important for the interaction with a putative target molecule. On the basis of this hypothesis, the ...