Efficient one-pot synthesis of 2-oxo-1, 9a-dihydro-2H-pyrido [1, 2-a] pyrimidine derivatives
M Adib, H Yavari, M Mollahosseini
Index: Adib, Mehdi; Yavari, Hossine; Mollahosseini, Mehdi Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1803 - 1805
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Citation Number: 29
Abstract
As part of our current studies on the development of new routes in heterocyclic synthesis, [10], [11], [12], [13] and [14] in this letter, we wish to report that pyridines 1 undergo a smooth reaction with dialkyl acetylenedicarboxylates 2 in the presence of isocyanates 3 in dry dichloromethane at ambient temperature to produce functionalized 2-oxo-1,9a-dihydro-2H-pyrido[1,2-a]pyrimidines 4 in 85–98% yields (Scheme 1). ... The 1 H NMR spectrum of 4a exhibited 15 two single ...
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