Synthesis of a novel, recyclable, solid-phase acylating reagent

RB Nicewonger, L Ditto, D Kerr, L Varady

Index: Nicewonger, Robert B; Ditto, Lori; Kerr, Doug; Varady, Laszlo Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 14 p. 1799 - 1802

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Citation Number: 25

Abstract

In this paper, we describe the synthesis of N-(6-cyano-1, 3-dimethyl-2, 4-dioxo-5-substituted- 1, 3-dihydropyridino [2, 3-d] pyrimidin-7-yl) imides 1. We will show the synthesis of 1 using both conventional heating and microwave techniques. In addition, the imide was attached to polystyrene and this immobilized imide was equally as effective at acylating various primary and secondary amines as its solution-phase counterpart.

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