Tetrahedron letters

Copper (II) tetrafluoroborate as a novel and highly efficient catalyst for N-tert-butoxycarbonylation of amines under solvent-free conditions at room temperature

SV Chankeshwara, AK Chakraborti

Index: Chankeshwara, Sunay V.; Chakraborti, Asit K. Tetrahedron Letters, 2006 , vol. 47, # 7 p. 1087 - 1091

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Citation Number: 61

Abstract

Commercially available copper (II) tetrafluoroborate hydrate was found to be a highly efficient catalyst for chemoselective N-tert-butoxycarbonylation of amines with di-tert-butyl dicarbonate under solvent-free conditions and at room temperature. Various aromatic amines were protected as their N-tert-butyl carbamates in high yields and in short times. No competitive side reactions such as isocyanate, urea, and N, N-di-t-Boc formation was ...