Tetrahedron Letters

Reaction of di (bromomagnesio) alkanes with unsymmetrically substituted cyclic anhydrides

P Canonne, G Lemay, D Bélanger

Index: Canonne, Persephone; Lemay, Gilles; Belanger, Denis Tetrahedron Letters, 1980 , vol. 21, p. 4167 - 4170

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Citation Number: 11

Abstract

Abstract Alkylated γ-spirolactones were prepared in one-step reactions in high yields from butane-1, 4-diyl and pentane-1, 5 diyldimagnesium dibromides and substituted cyclic anhydrides in tetrahydrofuran. In the light of experimental findings electronic and steric factors influence the regiospecificity of this reaction.