A mild and efficient chemoselective N-benzyloxycarbonylation of amines using TBAB as a catalyst under solvent-free conditions

KS Babu, VRS Rao, RR Rao…

Index: Babu, Kothamasu Suresh; Rao, Vidadala Rama Subba; Rao, Ravu Ranga; Babu, Sakhamuri Sivaram; Rao, Janaswami Madhusudana Canadian Journal of Chemistry, 2009 , vol. 87, # 2 p. 393 - 396

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Citation Number: 5

Abstract

We describe a mild and efficient method for the chemoselective N-benzyloxycarbonylation of amines by treatment of amines and aminoesters with benzyloxycarbonyl chloride (Cbz-Cl) in the presence of TBAB under solvent-free conditions in excellent yields. The method is general for the preparation of a wide variety of N-Cbz derivatives of aliphatic, aromatic amines, and aminoesters.