Journal of Fluorine Chemistry

Synthesis of α-Fluoroketones and α-Fluoroenones in Aqueous Media

Y He, X Zhang, N Shen, X Fan

Index: He, Yan; Zhang, Xinying; Shen, Nana; Fan, Xuesen Journal of Fluorine Chemistry, 2013 , vol. 156, p. 9 - 14

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Citation Number: 10

Abstract

Abstract An efficient synthesis of α-fluoroketones via the nucleophilic fluorination of α- bromoketones in water with TBAF· 3H 2 O as the fluorinating agent was developed in this paper. In addition, a simple and efficient synthesis of α-fluoroenones through the condensation of α-fluoroketones with aldehydes promoted by sodium hydroxide in water was also discovered.

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