The Journal of Organic Chemistry

New synthesis of 5-acyl-2-oxazolin-4-ones and of. beta.-keto-. alpha.-hydroxy acid amides from the reaction of 2, 2, 2-trialkoxy-2, 2-dihydro-1, 3, 2-dioxaphospholenes …

F Ramirez, CD Telefus

Index: Ramirez,F.; Telefus,C.D. Journal of Organic Chemistry, 1969 , vol. 34, # 2 p. 376 - 380

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Citation Number: 15

Abstract

A new reaction leading to 5-acyl-2-oxa~ olin-4-ones and to the corresponding hydrolysis products, p-keto-ahydroxy acid amides, is described. The reaction involves two steps:(1) the formation of a 2, 2, 2-trialkoxy-2, 2-dihydro-1, 3, 2-dioxaphospholerie from a trialkyl phosphite and an a-dicarbonyl compound and (2) the reaction of the phospholene with an acylisocyanate to yield the oxazolone and a trialkyl phosphate.