The search of novel inhibitors of HIV-1 integrase among 5-(4-halogenophenyl)-5-oxopentyl derivatives of nucleic bases
…, AV Atrokhova, MB Gottikh, AM Kritzyn
Index: Makinsky; Kritzyn; Ul'yanova; Zakharova; Bugreev; Nevinsky Russian Journal of Bioorganic Chemistry, 2001 , vol. 27, # 3 p. 167 - 172
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Abstract
Abstract New nucleic base derivatives were obtained by alkylation of uracil, thymine, cytosine, adenine, 6-chloropurine, and 2-amino-6-chloropurine with 5-chloro-1-(4- halogenophenyl)-1-pentanones, and their physical and chemical properties were studied.
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[Levy, Daniel E; Marlowe, Charles; Kane-Maguire, Kim; Bao, Ming; Cherbavaz, Diana B.; Tomlinson, James E.; Sedlock, David M.; Scarborough, Robert M. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3085 - 3088]