Synthesis and Evaluation of N, N-Di-n-propyltetrahydrobenz [f] indol-7-amine and Related Congeners as Dopaminergic Agonists

DE Nichols, JM Cassady, PE Persons…

Index: Nichols, David E.; Cassady, John M.; Persons, Paul E.; Yeung, Ming C.; Clemens, James A.; Smalstig, E. Barry Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2128 - 2134

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Citation Number: 23

Abstract

An evaluation of 6-[2-(di-n-propylamino) ethyl] indole (4), its rigid analogue N, N-di-n-propyl- 5, 6, 7, 8-tetrahydro-benz [flindol-7-amine (5), and some related congeners, for ability to suppress serum prolactin in reserpinized rats, revealed modest biological activity in this in vivo model of dopaminergic activity. Although the indole NH in these compounds can be considered to be oriented" meta" with respect to the ethylamine side chain, compounds ...