Tetrahydroquinoline derivatives as CRTH2 antagonists
…, D Marshall, S Miao, G Tonn, P Anders, J Tocker…
Index: Liu, Jiwen; Wang, Yingcai; Sun, Ying; Marshall, Derek; Miao, Shichang; Tonn, George; Anders, Penny; Tocker, Joel; Tang, H. Lucy; Medina, Julio Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6840 - 6844
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Citation Number: 31
Abstract
A series of tetrahydroquinoline-derived inhibitors of the CRTH2 receptor was discovered by a high throughput screen. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent and orally bioavailable CRTH2 antagonists.
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