Tetrahedron letters

Enantioselective synthesis of the aminoimidazole segment of dragmacidin D

CG Yang, J Wang, B Jiang

Index: Yang, Cai-Guang; Wang, Jun; Jiang, Biao Tetrahedron Letters, 2002 , vol. 43, # 6 p. 1063 - 1066

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Citation Number: 40

Abstract

A facile enantioselective synthesis of the 2-aminoimidazole side-chain of dragmacidin D has been developed, which involved the regio-and stereoselective opening of the chiral epoxide 9 by a diindolylcuprate reagent, followed by further steps to give 5-substituted N-(1H- imidazol-2-yl) acetamide 2.