Evaluation of azasterols as anti-parasitics

…, LM Ruiz-Perez, D Gonzalez-Pacanowska…

Index: Gros, Ludovic; Lorente, Silvia Orenes; Jimenez, Carmen; Yardley, Vanessa; Rattray, Lauren; Wharton, Hayley; Little, Susan; Croft, Simon L.; Ruiz-Perez, Luis M.; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H. Journal of Medicinal Chemistry, 2006 , vol. 49, # 20 p. 6094 - 6103

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Citation Number: 62

Abstract

In this article, the design and synthesis of some novel azasterols is described, followed by their evaluation against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, and Plasmodium falciparum, the causative agents of human African trypanosomiasis, Chagas disease, leishmaniasis, and malaria, respectively. Some of the compounds showed anti-parasitic activity. In particular, a number of compounds appeared to very potently ...