1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis …

…, C Brullo, F Bondavalli, S Schenone, S Spisani…

Index: Bruno, Olga; Brullo, Chiara; Bondavalli, Francesco; Schenone, Silvia; Spisani, Susanna; Falzarano, Maria Sofia; Varani, Katia; Barocelli, Elisabetta; Ballabeni, Vigilio; Giorgio, Carmine; Tognolini, Massimiliano Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 9 p. 3379 - 3387

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Citation Number: 12

Abstract

In this paper we report the synthesis and the chemotaxis inhibitory activity of a number of 1H- pyrazole-4-carboxylic acid ethyl esters 2 functionalized in N1 with a methyl group or different hydroxyalkyl chains and in position 5 with a series of 3-substituted urea groups. These compounds were designed as development of previous pyrazole-urea derivatives that resulted potent IL8-induced neutrophil chemotaxis inhibitors in vitro. Most of the new ...