A versatile method for the N, N-dialkylation of aromatic amines via Grignard reactions on N, N-bis (benzotriazolylmethyl) arylamines
AR Katritzky, S Rachwal, J Wu
Index: Katritzky, Alan R.; Rachwal, Stanislaw; Wu, Jing Canadian Journal of Chemistry, 1990 , vol. 68, # 3 p. 456 - 463
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Citation Number: 17
Abstract
Grignard reactions of N, N-bis (benzotriazolylmethyl) arylamines afford the corresponding N, N-dialkylarylamines in high yields. Electron-releasing substituents on the aryl ring facilitate the reaction. Arylamines are N, N-dialkylated with two different alkyl groups by a stepwise procedure: N-benzotriazolylmethylation of an amine followed by a Grignard reaction to introduce the first alkyl group, and repetition of the same procedure to introduce the ...
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