Adaptation of Staphylococcus aureus to synthetic triazolides

…, ZP Belousova, AI Ivanchina, EI Ten'gaev

Index: Selezneva; Belousova; Ivanchina; Ten'gaev Pharmaceutical Chemistry Journal, 2006 , vol. 40, # 3 p. 145 - 148

Full Text: HTML

Citation Number: 2

Abstract

Abstract The ability of Staphylococcus aureus to adapt to the toxic action of 1, 2, 4-triazole and its sulfuryl derivates has been studied. A positive correlation is found between the lipophilicity and toxicity of substances. It is established that methylated derivates are more toxic than substances without methyl radicals. St. aureus species grown on a medium containing triazolides in a nontoxic dose become resistant to highly toxic doses of these ...