Kinetics and Mechanism of Certain Acetylation Reactions with Acetamide/Oxychloride in Acetonitrile under Vilsmeier Haack Conditions

M Venkateswarlu, M Satish Kumar…

Index: Venkateswarlu, Marri; Satish Kumar, Mukka; Ramgopal, Soma; Rajanna, Kamatala Chinna; Umesh Kumar, Utkoor; Uppalaiah, Kusampally; Saiprakash, Pondichery Kuppuswamy Helvetica Chimica Acta, 2011 , vol. 94, # 12 p. 2168 - 2187

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Citation Number: 6

Abstract

Abstract Vilsmeier [BOND] Haack (VH) acetylation reactions with benzaldehydes or acetophenones in MeCN followed second-order kinetics and afforded acetyl derivatives under kinetic conditions, irrespective of the nature of the oxychloride (SOCl 2 or POCl 3) used for the preparation of the VH reagent along with acetamide. The present finding contributes to the understanding of the nature of the reactive species of the VH reagent as ...