Bioscience, biotechnology, and biochemistry

Synthesis of (1 R, 2 S)-1-(3′-Chloro-4′-methoxyphenyl)-1, 2-propanediol (Trametol) and (1 R, 2 S)-1-(3′, 5′-Dichloro-4′-methoxyphenyl)-1, 2-…

T Kousaka, K Mori

Index: Bioscience, Biotechnology and Biochemistry, , vol. 66, # 3 p. 697 - 701

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Abstract

... Biotechnol. Biochem., 66 (3), 697–701, 2002 Note ... [a]D: Jasco P-1020. nD: Atago NAR-1T. ... Methyl 3-chloro-4-methoxybenzoate (6). 3-Chloro- 4-hydroxybenzoic acid (5, 1.00 g, 5.79 mmol) was dissolved in dry acetone (46 ml), to which was added K2CO3 (2.40g, 17.4mmol). ...