Synthetic Communications

Application of Odorless Thiols for the Cleavage of 2??and 4??Nitrobenzenesulfonamides

M Matoba, T Kajimoto, M Node

Index: Matoba, Manabu; Kajimoto, Tetsuya; Node, Manabu Synthetic Communications, 2008 , vol. 38, # 8 p. 1194 - 1200

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Citation Number: 9

Abstract

Abstract Several odorless or faint??smelling thiols were tested to cleave 2??and 4?? nitrobenzenesulfonyl groups, which are widely utilized for selective protection and activation of amines. p??Mercaptobenzoic acid (7) was found to be the most useful thiol for cleaving the o??and p??nosyl groups in terms of ease of separation of the product from the workup residue, reaction temperature, and reaction time.