An investigation of phenylthiazole antiflaviviral agents
AS Mayhoub, M Khaliq, C Botting, Z Li, RJ Kuhn…
Index: Mayhoub, Abdelrahman S.; Khaliq, Mansoora; Kuhn, Richard J.; Cushman, Mark Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1704 - 1714
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Citation Number: 24
Abstract
Abstract Flaviviruses are one of the most clinically important pathogens and their infection rates are increasing steadily. The phenylthiazole ring system has provided a template for the design and synthesis of antiviral agents that inhibit the flaviviruses by targeting their E- protein. Unfortunately, there is a correlation between phenylthiazole antiflaviviral activity and the presence of the reactive and therefore potentially toxic mono-or dibromomethyl ...
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