Practical iron-catalyzed dehalogenation of aryl halides

…, S Grupe, M Mayer, AJ von Wangelin

Index: Czaplik, Waldemar Maximilian; Grupe, Sabine; Mayer, Matthias; Wangelin, Axel Jacobi Von Chemical Communications, 2010 , vol. 46, # 34 p. 6350 - 6352

Full Text: HTML

Citation Number: 3

Abstract

An operationally simple iron-catalyzed hydrodehalogenation of aryl halides has been developed with 1 mol% Fe (acac) 3 and commercial t-BuMgCl as reductant. The mild reaction conditions (THF, 0° C, 1.5 h) effect rapid chemoselective dehalogenation of (hetero) aryl halides (I, Br, Cl) and tolerate F, Cl, OR, SR, CN, CO2R, and vinyl groups.