Arkivoc

The effect of substituents on the syn-anti conformer ratio in naphthyl-based imidazolinium salts and their corresponding N-heterocyclic carbenes

…, E Drinkel, F Gaggia, S Blumentritt, A Linden, R Dorta

Index: Gatti, Michele; Wu, Linglin; Drinkel, Emma; Gaggia, Fiona; Blumentritt, Sascha; Linden, Anthony; Dorta, Reto Arkivoc, 2011 , vol. 2011, # 6 p. 176 - 198

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Citation Number: 3

Abstract

Abstract Eight new N-heterocyclic carbenes (NHCs) featuring substituted naphthyl side chains were synthesized. These molecules are present in solution as a stable mixture of anti and syn conformers. Through careful tuning of the substituents on position 2 and 2, 7 of the naphthyl moieties, it was possible to synthesize molecules that display a strong preference for the anti conformation (up to 95: 5). This will greatly facilitate their optimized use as ...