Tetrahedron Letters

Organic synthesis in deep eutectic solvents: Paal–Knorr reactions

S Handy, K Lavender

Index: Handy, Scott; Lavender, Kevin Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4377 - 4379

Full Text: HTML

Citation Number: 36

Abstract

Abstract Deep eutectic solvents (the combination of either urea or glycerol with choline chloride) are effective solvents/catalysts for Paal–Knorr reactions to form pyrroles of furans. The reaction conditions are quite mild and do not require the addition of an additional Bronsted or Lewis acid catalyst. Given the inexpensive, non-toxic, and recyclable nature of the DES, these reaction conditions are simple and highly environmentally friendly.