Biologically useful chelators that take up calcium (2+) upon illumination

SR Adams, JPY Kao, RY Tsien

Index: Adams, S. R.; Kao, J. P. Y.; Tsien, R. Y. Journal of the American Chemical Society, 1989 , vol. 111, # 20 p. 7957 - 7968

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Citation Number: 187

Abstract

Abstract: Two approaches were explored toward the goal of synthesizing physiologically useful Caz+-selective chelators whose Ca2+ affinities increase markedly upon photolysis. In the first approach, the known Ca2+-selective chelator 1, 2-bis (o-aminophenoxy) ethane-N, N, N', N'-tetraacetic acid (BAPTA) was masked with a variety of photoremovable protecting groups on one of its four carboxyl groups, reducing its affinity for Ca2+ to-lo5 M-'. Upon ...