Tetrahedron

Synthesis of febrifugine derivatives and a solution to the puzzle of the structural determination of febrifugine

…, M Oshige, H Abe, H Nishioka, K Sasaki, T Harayama

Index: Takeuchi, Yasuo; Azuma, Kumiko; Oshige, Miyo; Abe, Hitoshi; Nishioka, Hiromi; Sasaki, Kenji; Harayama, Takashi Tetrahedron, 2003 , vol. 59, # 10 p. 1639 - 1646

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Citation Number: 15

Abstract

The stereo-structure of piperidine lactone (3), a synthetic intermediate of the antimalarial agent febrifugine ((+)-1) with a piperidine ring in the trans relative configuration, was re- revised to the cis-form. We determined that isomerization to the trans-form from the cis- ...