Ring-contraction reactions of dihydro-and tetrahydrothiazepines to isothiazolone derivatives under Pummerer conditions

K Yamamoto, S Yamazaki, I Murata…

Index: Yamamoto, Kagetoshi; Yamazaki, Shoko; Murata, Ichiro; Fukazawa, Yoshimasa Journal of Organic Chemistry, 1987 , vol. 52, # 23 p. 5239 - 5243

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Citation Number: 19

Abstract

In general, conjugated seven-membered sulfur heterocycles such as thiepines2 and thiazepines3 are thermally unstable owing to their ready sulfur extrusion. It has already been demonstrated that the instability of these heterocycles can be largely overcome by introducing two bulky groups at both neighbors of the sulfur atom. 4 Recently we have reported the first synthesis of a stable monocyclic l, Cthiazepine, 2, 7-di-tert-butyl-5- ...