Phosphorescence imaging of living cells with amino acid-functionalized tris (2-phenylpyridine) iridium (III) complexes

P Steunenberg, A Ruggi, NS van den Berg…

Index: Steunenberg, Peter; Ruggi, Albert; Van Den Berg, Nynke S.; Buckle, Tessa; Kuil, Joeri; Van Leeuwen, Fijs W.B.; Velders, Aldrik H. Inorganic Chemistry, 2012 , vol. 51, # 4 p. 2105 - 2114

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Citation Number: 34

Abstract

A series of luminescent fully cyclometalated octahedral iridium (III) 2-phenylpyridine complexes functionalized with three different amino acids, on one, two, or all three of the phenylpyridine ligands has been synthesized and characterized. Cellular uptake and localization have been studied with flow cytometry and confocal microscopy, respectively. The monosubstituted iridium (III) complexes gave the highest cellular uptake, and the ...