Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping

CM Richardson, CL Nunns, DS Williamson…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 14 p. 3880 - 3885

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Citation Number: 35

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... With the aid of X-ray crystallography and modelling, a medicinal chemistry strategy was implemented to probe the ... Detailed modelling work was unable to assign the chemical structure unambiguously, with both E- and Z-isomers having ...