Tetrahedron letters

N-Perhalofluoroalkylation of secondary amines by the reactions of the amines and amides with perhalofluoroalkanes. Halophilic attack on nitrogen nucleophile on C …

X Li, H Pan, X Jiang

Index: Li, Xing-ya; Pan, He-qi; Jiang, Xi-kui Tetrahedron Letters, 1987 , vol. 28, # 32 p. 3699 - 3702

Full Text: HTML

Citation Number: 24

Abstract

Abstract Secondary amines and amides react spontaneously with perhalofluoroalkanes CF 2 BrCFBrX (X= F, Cl, CF 3) to afford N-perhalofluoroalkylated tertiary amines in fair to good yields. Evidence for an anionic chain process initiated by the bromophilic attack of nitrogen