Synlett

Cumyl: A Better N-Protecting Group of α-Diazo Acetamides for Intramolecular CH Insertion Reaction and its Application in the Synthesis of Pregabalin and 3- …

Z Chen, Z Chen, Y Jiang, W Hu

Index: Chen, Zhenliang; Chen, Zhiyong; Jiang, Yaozhong; Hu, Wenhao Synlett, 2004 , # 10 p. 1763 - 1764

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Citation Number: 5

Abstract

Abstract Via intramolecular CH insertion of N-cumyl α-diazo acetamides, γ-lactams were efficiently synthesized with excellent regioselectivity. A concise route for the preparation of pregabalin (79% overall yield) and 3-benzyloxy pyrrolidine (21% overall yield) were reported.