… symmetrically and unsymmetrically substituted 1, 4-bis [(aminoalkyl) amino] anthracene-9, 10-diones and 1, 4-bis [(aminoalkyl) amino]-5, 8-dihydroxyanthracene-9, 10 …

AP Krapcho, Z Getahun, KL Avery Jr…

Index: Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth L.; Vargas, Kevin J.; Hacker, Miles P.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2373 - 2380

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Citation Number: 54

Abstract

Conclusion The significant increase of the thermal, chemical, and photochemical stability of the chromophore in the complexed formw is likely a result of the following interactions:(1) the hydrophobic environment of the epoxide and the unsaturated bonds;(2) steric coverage of the active reaction site ((212) with Phe78 and the methyl group (C6') of the amino sugar moiety;(3) stabilization of a rigid conformation of the chromophore by a network of ...