Molecules

Microwave Accelerated Aza-Claisen Rearrangement

E Gajdošíková, M Martinková, J Gonda, P Conka

Index: Gajdosikova, Eva; Martinkova, Miroslava; Gonda, Jozef; Conka, Patrik Molecules, 2008 , vol. 13, # 11 p. 2837 - 2847

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Citation Number: 10

Abstract

Abstract: A study of microwave-induced and standard thermal Overman rearrangement of selected allylic trichloroacetimidates 1a-1f, 6-8 to the corresponding acetamides 2a-2f, 9-11 is reported. The microwave-assisted rearrangement of trifluoroacetimidate 13 is also described. Using this methodology, an efficient access to versatile allylic trihaloacetamides building synthons was established.