First Metal-Containing Histamine H3 Receptor Ligands†
K Sander, T Kottke, C Hoffend, M Walter, L Weizel…
Index: Sander, Kerstin; Kottke, Tim; Hoffend, Claas; Walter, Miriam; Weizel, Lilia; Camelin, Jean-Claude; Ligneau, Xavier; Schneider, Erich H.; Seifert, Roland; Schwartz, Jean-Charles; Stark, Holger Organic Letters, 2010 , vol. 12, # 11 p. 2578 - 2581
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Citation Number: 17
Abstract
Iron-containing ligands targeting the human histamine H3 receptor (h H3R) were prepared. The compounds contain ferrocene sandwich complexes coupled via different linkers to a basic h H3R antagonist/inverse agonist pharmacophore. In a click chemistry approach, a triazole was successfully inserted as a new linking element. Two ferrocenylmethylamines and a ferrocenyltriazole were the most affine h H3R ligands within this series, showing ...
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