Studies on the. BETA.-turn of peptides. VII. Syntheses and antibiotic activities of gramicidin S analogs with L-Pro-L-Asn or L-Pro-D-Ala sequence at the. BETA.-turn …
K Sato, U Nagai
Index: Sato; Nagai Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 11 p. 3329 - 3336
Full Text: HTML
Citation Number: 15
Abstract
Two analogs of gramicidin S (GS),[L-Pro 4, 4′, L-Asn 5, 5′]-GS (10a) and [L-Pro 4, 4′, D- Ala 5, 5′]-GS were synthesized to investigate the possibility of replacing the β-turn part of GS by a different type of β-turn keeping the biological activity. For the synthesis of 10a, three procedures were examined and satisfactory results were obtained by the active ester method applied to cyclization of linear decapeptide with L-Pro at the C-terminus. Neither ...
Related Articles:
[Salomon, Claudio J.; Mata, Ernesto G.; Mascaretti, Oreste A. Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 10 p. 995 - 999]
[Namikoshi, Michio; Kundu, Bijoy; Rinehart, Kenneth L. Journal of Organic Chemistry, 1991 , vol. 56, # 18 p. 5464 - 5466]
Phenylhydrazide as an enzyme-labile protecting group in peptide synthesis
[Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910]
A progressive synthetic strategy for class B synergimycins
[Robinson, Jennifer L.; Taylor, Rachel E.; Liotta, Lisa A.; Bolla, Megan L.; Azevedo, Enrique V.; Medina, Irene; McAlpine, Shelli R. Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2147 - 2150]
Phenylhydrazide as an enzyme-labile protecting group in peptide synthesis
[Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910]