Novel antifungal β-amino acids: synthesis and activity against Candida albicans

J Mittendorf, F Kunisch, M Matzke, HC Militzer…

Index: Mittendorf, Joachim; Kunisch, Franz; Matzke, Michael; Militzer, Hans-Christian; Schmidt, Axel; Schoenfeld, Wolfgang Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 433 - 436

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Citation Number: 106

Abstract

A series of novel β-amino acids has been synthesized and tested for their in vitro antifungal activity against Candida albicans. A steep SAR was observed. β-Amino acid 21 (BAY 10- 8888/PLD-118) revealed the most favourable activity–tolerability profile and was selected for clinical studies as a novel antifungal for the oral treatment of yeast infections.