Bioorganic Chemistry

Methyltrypsin-Catalyzed Peptide Coupling: Comparison of Alkyl Ester and Guanidinophenyl Ester Derivatives as Acyl Donor Component

K Itoh, H Sekizaki, E Toyota, K Tanizawa

Index: Itoh, Kunihiko; Sekizaki, Haruo; Toyota, Eiko; Tanizawa, Kazutaka Bioorganic Chemistry, 1997 , vol. 25, # 5-6 p. 307 - 319

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Abstract

Methyltrypsin-catalyzed peptide synthesis has been studied by using conventional alkyl ester andp-guanidinophenyl ester derivatives of α-amino acid as the acyl donor component. They were found to be coupled with α-amino acid derivatives (acyl acceptor component) to produce dipeptide. The behavior of methyltrypsin toward both the substrates has been studied.