Flavonoids: structural requirements for antiproliferative activity on breast cancer cells

C Pouget, F Lauthier, A Simon, C Fagnere…

Index: Pouget, Christelle; Lauthier, Fabienne; Simon, Alain; Fagnere, Catherine; Basly, Jean-Philippe; Delage, Christiane; Chulia, Albert-Jose Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 24 p. 3095 - 3097

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Citation Number: 114

Abstract

Several classes of flavonoids (flavones, flavanones, 2′-hydroxychalcones and flavan-4-ols) having a variety of substituents on A ring were investigated for their antiproliferative activity against MCF-7 human breast cancer cells. Structure–activity relationships of these compounds were discussed. 2′-hydroxychalcones and methoxylated flavanones were found to be potent inhibitors of MCF-7 cells growth whereas flavones and flavan-4-ols ...