Solid-phase traceless synthesis of selected nitrogen-containing heterocyclic compounds. The Encore technique for directed sorting of modular solid support

V Krchňák, J Smith, J Vágner

Index: Krchnak, Viktor; Smith, Jennifer; Vagner, Josef Collection of Czechoslovak Chemical Communications, 2001 , vol. 66, # 7 p. 1078 - 1106

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Citation Number: 21

Abstract

Abstract The acid lability of electron-rich N-benzylanilines has been exploited in a linker for the traceless solid-phase synthesis of benzimidazoles, 2-aminobenzimidazoles, quinoxalinones and tetrahydroquinoxalines. The target compound precursors were assembled on a solid-phase support derivatized with either a benzylamine or a benzhydrylamine linker. Exposure to an acidic reagent caused cleavage of the C (benzyl)- ...