A practical stereospecific synthesis of the biotin precursor (3aα, 6aα)-1, 3-dibenzylhexahydro-1 H-thieno [3, 4-d] imidazol-2 (3 H)-one 1, 1-dioxide

HA Bates, L Smilowitz, SB Rosenblum

Index: Bates, Hans Aaron; Smilowitz, Lloyd; Rosenblum, Stuart B. Journal of the Chemical Society, Chemical Communications, 1985 , # 6 p. 353 - 354

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Abstract

A highly efficient stereospecific synthesis of the biotin precursor (3aα, 6aα)-1, 3- dibenzylhexahydro-1H-thieno [3, 4-d] imidazol-2 (3H)-one 1, 1-dioxide (6) is reported, by the cyclisation of the urea (5), which was obtained from the amine (4),(4) itself being prepared by the reaction of the dibromide (2) with benzylamine.