Novel cerebroprotective agents with central nervous system stimulating activity. 2. Synthesis and pharmacology of the 1-(acylamino)-7-hydroxyindan derivatives

Y Oshiro, Y Sakurai, T Tanaka, T Kikuchi…

Index: Oshiro; Sakurai; Tanaka; Kikuchi; Hirose; Tottori Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2014 - 2023

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Citation Number: 28

Abstract

In a continuous search for a novel cerebroprotective drug with a central nervous system (CNS) stimulating activity, a series of l-(acylamino)-7-hydroxyindan derivatives has been synthesized and tested for ita dual activities. The cerebroprotective activities of the compounds in this series were evaluated in terms of their effect on the survival of mice in hypoxic conditions (210 mmHg), and their CNS stimulating activities were examined by ...