An Enantioselective Synthesis of cis??4??tert??Butoxycarbamoyl??1??methoxycarbonyl??2??cyclopentene—A Useful, General Building Block

BM Trost, D Stenkamp, SR Pulley

Index: Trost, Barry M.; Stenkamp, Dirk; Pulley, Shon R. Chemistry--A European Journal, 1995 , vol. 1, # 8 p. 568 - 572

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Citation Number: 36

Abstract

Abstract The amino acid derivative in the title represents an important building block for the synthesis of a number of biologically important targets such as the antiviral carbanucleosides and amidinomycin. By using asymmetric palladium-catalyzed desymmetrization of meso-2-ene-1, 4-diols, cis-1, 4-dibenzoyloxy-2-cyclopentene can be converted to the enantiomerically pure title compound in only four steps. Chemoselective ...