Journal of fluorine chemistry

3-Fluorobenzodiazepines

WJ Middleton, EM Bingham, DH Smith

Index: Middleton, W. J.; Bingham, E. M.; Smith, D. H. Journal of Fluorine Chemistry, 1983 , vol. 23, p. 557 - 572

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Citation Number: 7

Abstract

Abstract Benzodiazepines that bear a fluorine substituent in the metabolically active C-3 position were prepared by the reaction of diethylaminosulfur trifluoride (DAST) with the corresponding 3-hydroxybenzodiazepines. These products are surprisingly stable to hydrolysis and possess potent antianxiety and muscle-relaxing properties.