… and excitatory amino acid receptor ligands. Part 1: Synthesis and pharmacological evaluation of the benzylic oxidation series of 1, 4-dihydro-6, 7-dimethyl-2, 3- …

…, LJ Wallace, DM Weinstein, G Shams, CC Garris…

Index: Bhat, Ajita; Chang, Hui-Min; Wallace, Lane J.; Weinstein, David M.; Shams, Gamal; Garris, Cynthia C.; Hill, Ronald A. Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 3 p. 271 - 282

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Citation Number: 11

Abstract

A series of five 6, 7-disubstituted 1, 4-dihydro-2, 3-quinoxalinediones was prepared, two of which are known microbial flavin metabolites and three of which are potential flavin metabolites. Four of the five compounds inhibited specific binding of [3H]-amino-3-hydroxy-5- methyl-4-isoxazolepropanoic acid ([3H] AMPA),[3H] kainic acid, and [3H] 6-cyano-1, 4- dihydro-7-nitro-2, 3-quinoxalinedione ([3H] CNQX) in rat brain homogenate fractions, with ...