Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides

E De Clercq, J Descamps, J Balzarini…

Index: De Clerq; Descamps; Balzarini; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 661 - 666

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Citation Number: 129

Abstract

Coupling of terminal alkynes with 5-iodo-1-(2, 3, 5-tri-Op-toluyl-~-~-arab~ nofuranosyl) uracil and 5-iodo-3', 5'-di-0-p-toluyl-2'-deoxyuridine proceeded readily in triethylamine with catalytic quantities of bis (tripheny1phosphine)-palladium (I1) chloride and copper (1) iodide. The resulting products were deprotected to give 5-alkynyl-l-@-~- arabinofuranosyluracil and 5-alkynyl-2'-deoxyuridine nucleosides. The 5-ethynyl, followed ...