Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors

…, P Curzon, YJ Cao, P Puttfarcken…

Index: Klemm, L. H.; Louris, John N. Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 785 - 790

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Citation Number: 45

Abstract

... Journal of Medicinal ... Several N-(3-pyridinyl) derivatives of bridged bicyclic diamines exhibit double-digit-picomolar binding affinities for the α4β2 subtype ... is represented by compound R-8, in which the critical stereogenic center is eliminated by replacement of nitrogen for carbon. ...