Synthesis of N-(2-phosphonylmethoxyethyl) derivatives of heterocyclic bases

A Holý, I Rosenberg, H Dvořáková

Index: Holy, Antonin; Rosenberg, Ivan; Dvorakova, Hana Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 8 p. 2190 - 2210

Full Text: HTML

Citation Number: 90

Abstract

Abstract The preparation of N-(2-phosphonylmethoxyethyl) derivatives of purine and pyrimidine bases, IV, as analogs of the antiviral 9-(2-phosphonylmethoxyethyl) adenine (PMEA, I), is described. The synthesis consists in alkylation of alkali metal salts of heterocyclic bases or their N-or O-substituted derivatives with diethyl 2-p- toluenesulfonyloxyethoxymethylphosphonate (IIa), 2-chloroethoxymethylphosphonate (IIb ...