Discovering some novel 7-chloroquinolines carrying a biologically active benzenesulfonamide moiety as a new class of anticancer agents

MS Al-Dosari, MM Ghorab, MS Al-Said…

Index: Al-Dosari, Mohammed Salem; Ghorab, Mostafa Mohamed; Al-Said, Mansour Sulaiman; Nissan, Yassin Mohammed Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 1 p. 50 - 58

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Citation Number: 20

Abstract

Based on the reported anticancer activity of quinolines, a new series of 7-chloroquinoline derivatives bearing the biologically active benzenesulfonamide moiety 2–17 and 19–25 were synthesized starting with 4, 7-dichloroquinolne 1. Compound 17 was the most active compound with IC 50 value 64.41, 75.05 and 30.71 µM compared with Doxorubicin as reference drug with IC 50 values 82.53, 88.32 and 73.72 µM on breast cancer cells, skin ...