Synthesis

Chemoenzymatic Synthesis of (S)-8-O-Methylmellein by Candida parapsilosis Carbonyl Reductase

T Schubert, MR Kula, M Müller

Index: Schubert, Thomas; Kula, Maria-Regina; Mueller, Michael Synthesis, 1999 , # 12 p. 2045 - 2048

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Citation Number: 4

Abstract

Abstract: A screening of various orthosubstituted 2-oxopropylbenzene derivatives with carbonyl reductases and alcohol dehydrogenases, respectively, revealed that compounds containing ortho-substituents with only little steric demand are feasible substrates.(S)-8-O- Methylmellein (1) was synthesized by stereoselective enzymatic reduction of 2-methoxy-6-(2- oxopropyl) benzonitrile (5i) with Candida parapsilosis carbonyl reductase as the key step, ...

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