Tetrahedron

The absolute configuration of a hypolipidemic 1-aryl tetralin, nafenopin

WL Bencze, B Kisis, RT Puckett, N Finch

Index: Bencze,W.L. et al. Tetrahedron, 1970 , vol. 26, p. 5407 - 5414

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Citation Number: 10

Abstract

A new hypolipidemic agent, 2-methyl-2-[p-(1, 2, 3, 4-tetrahydro-1-napthyl) phenoxy] propionic acid, has been resolved. The absolute configurations of the enantiomers have been established by (a) ORD correlation with the lignans (b) application of the ORD skewed styrene rule to the derived dehydro compound and (c) the Bijvoet X-ray procedure on an iodo derivative.