Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity

Y Takase, T Saeki, N Watanabe, H Adachi…

Index: Journal of Medicinal Chemistry, , vol. 37, # 13 p. 2106 - 2111

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Citation Number: 63

Abstract

... We therefore 0022-2623/94/1837-2106$04.50/0 Q 1994 American Chemical Society Page 2. Cyclic GMP Phosphodiesterase Inhibitors. 2 Journal of Medicinal Chemistry, 1994, Vol. 37, No. 13 2107 Scheme 1 0 HCONH, POCI, R- H, Me, or Et lb-n ...